Use of Adalimumab in young patients with chronic uveitis in whom infliximab loses its efficacy
نویسندگان
چکیده
Materials and methods We have switched to Adalimumab treatment eight patients with chronic uveitis in whom, after 15–39 months of Infliximab infusions, recurrences of eye inflammations were increasing. Four were males, four females; in three cases uveitis was associated with JIA, in one with early-onset sarcoidosis, in one with Behçet disease, while three patients suffered from idiopathic uveitis. Adalimumab was administered subcutaneously at the dosage of 24 mg/sq. meter every 2 weeks. Up to now (April 2008) patients received from 18 to 24 injections each.
منابع مشابه
[Efficacy of adalimumab in Behçet's disease. Description of 6 cases].
Behçet's disease (BD) is a systemic vasculitis, with a more aggressive course in young males. Orogenital ulcers, uveitis and cutaneous lesions are the most frequent manifestations. We analyzed the effects of adalimumab on six patients with BD pretreated with inmunosupressive therapy, two of whom had received infliximab. We observed a good clinical response in all patients. To date, after a mean...
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The SpAs are a group of overlapping, chronic, inflammatory rheumatic diseases including AS, a chronic inflammatory disease primarily affecting the SI joints. In addition to inflammatory back pain, AS patients are also more likely to experience extra-articular manifestations belonging to the SpA concept which can affect the eyes, the gastrointestinal tract and the skin and other related inflamma...
متن کاملAnti-tumour necrosis factor (anti-TNF) in the treatment of juvenile idiopathic arthritis-associated uveitis
Results Of the 16 patients, 10 were treated with etanercept (62.5%), 1 with adalimumab (6.25%), and 5 (31.2%) with infliximab. Notably, two cases of uveitis were associated with use of etanercept. In 5 patients (31.2%) the antiTNF was changed because of lack of efficacy and/or side effects to another one (in 4/5 adalimumab). Ten patients had a complicated uveitis (cataract in 5). The number of ...
متن کاملSuperior efficacy of Adalimumab in treating childhood refractory chronic uveitis when used as first biologic
Methods 26 patients (14 F, 12 M; median age: 8.6 years) with refractory, vision threatening, non-infectious active uveitis were enrolled. Due to the refractory course of uveitis to previous DMARD treatment, Group 1 received Adalimumab (24 mg/sq mt, every 2 weeks), as first antiTNFa choice; Group 2 received Adalimumab, as second anti-TNFa drug, due to the loss of efficacy of Infliximab, after a ...
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